Peptide ndeye organic compound, iyo inopera mvura kubva kumaamino acids uye ine carboxyl uye amino mapoka.Icho chinhu chinonzi amphoteric compound.Polypeptide ikamu rinoumbwa nemaamino acids akabatanidzwa pamwechete ne peptide bond.Icho chigadzirwa chepakati cheprotein hydrolysis.Iyo inoumbwa nekupera mvura mumuviri uye condensation ye10 ~ 100 amino acid mamorekuru, uye huremu hwayo hwemamorekuru huri pasi pe10000Da.Inogona kupinda mukati memembrane-permeable uye haina kunatswa ne trichloroacetic acid uye ammonium sulfate, kusanganisira bioactive peptides uye artificial synthetic peptides.
Mishonga yePolypeptide inoreva mapolypeptides ane chaiwo maitiro ekurapa kuburikidza nemakemikari synthesis, gene recombination uye mhuka nekudyara kutorwa, izvo zvinonyanya kukamurwa kuita endogenous polypeptides (senge enkephalin uye thymosin) uye mamwe exogenous polypeptides (senge uturu hwenyoka uye sialic acid).Huremu hwemamorekuru emishonga yepolypeptide iri pakati peprotein zvinodhaka uye micromolecule mishonga, ine zvakanakira micromolecule mishonga uye mapuroteni zvinodhaka.Kuenzaniswa nemishonga ine micromolecule, polypeptide mishonga ine yakakwirira biological chiitiko uye yakasimba chaiyo.Kuenzaniswa nemishonga yemapuroteni, polypeptide mishonga ine kugadzikana kuri nani, kuderera kwekudzivirira muviri, kuchena kwakanyanya uye mutengo wakaderera.
Polypeptide inogona kuve yakananga uye nekushingaira kunyudzwa nemuviri, uye kukurumidza kunyura kunokurumidza, uye kutorwa kwepolypeptide kune yekutanga.Mukuwedzera, peptides haigoni kutakura zvinovaka muviri chete, asiwo kutumira ruzivo rwemaserura kuraira tsinga.Mishonga yePolypeptide ine hunhu hwekuita kwepamusoro, kusarudzwa kwepamusoro, huturu hwakaderera uye hukama hwakanangana, asi panguva imwe chete, ivo vanewo zvakaipira zvepfupi hafu yehupenyu, hurombo cell membrane permeability uye nzira imwechete yekutonga.
Tichifunga nezvekukanganisa kwemishonga yepolypeptide, vaongorori vakaita nhamburiko dzisingaperi munzira yekuvandudza peptides kuvandudza bioavailability yemishonga yepolypeptide.Kutenderera kwepeptides ndiyo imwe yenzira dzekukwirisa peptides, uye kuvandudzwa kwemacyclic peptides kwaunza mambakwedza kumishonga yepolypeptide.Cyclic peptides inobatsira kumushonga nekuda kwekugadzikana kwavo kwemetabolism, kusarudza uye hukama, cell membrane permeability uye kuwanikwa kwemuromo.Cyclic peptides ine biological zviitiko zvakaita se anti-cancer, anti-infection, anti-fungus uye anti-virus, uye ari kuvimbisa mamorekuru emishonga.Mumakore achangopfuura, cyclic peptide mishonga yakakwezva kutarisisa kukuru, uye makambani emishonga akatevera maitiro ekuvandudza zvinodhaka uye akaisa cyclic peptide mishonga yemishonga imwe mushure meimwe.
Dr. Chen Shiyu kubva kuShanghai Institute of Pharmacology, Chinese Academy of Sciences yakaunza mishonga yecyclic peptide yakagamuchirwa kubva muna 2001 kusvika 2021 mumishonga yayo yecyclic peptide yakagamuchirwa mumishonga miviri yekupedzisira.Mumakore makumi maviri adarika, pane marudzi gumi nemasere emishonga yemacyclic peptide pamusika, pakati pawo nhamba yemacyclic peptides inoshanda pa cell wall synthesis uye β-1,3- glucanase targets ndiyo hombe, ine marudzi matatu imwe neimwe.Iyo yakabvumidzwa cyclic peptide mishonga inovhara anti-utachiona, endocrine, digestive system, metabolism, bundu / kusadzivirirwa uye yepakati tsinga sisitimu, pakati peiyo anti-utachiona uye endocrine cyclic peptide mishonga inoita 66.7%.Panyaya yemhando dzecyclization, kune akawanda cyclic peptide mishonga inofambiswa ne disulfide bond uye yakafambiswa nema amide bond, uye 7 uye 6 mishonga yakabvumidzwa zvichiteerana.
Nguva yekutumira: Sep-18-2023