Chirwere chemoyo, chinova ndicho chikonzero chikuru chekufa kwezvirwere zvisingatapurirane, chirwere chinokonzerwa nekuchembera.Nekuwedzera kwezera, moyo, senhengo yekupomba ropa, ichachembera, uye kugona kwayo kuzorora uye chibvumirano kuchaderera, uye zvishoma nezvishoma haizokwanisa kupomba ropa kumuviri wese, izvo zvinozopedzisira zvaita kuti moyo ushaye simba. varwere uye zvinokanganisa zvakanyanya hutano hwevanhu hupenyu.
Kuchembera kwemoyo kunoonekwa nekudzikira kwe cardiac contractility ( cardiac function ), izvo zvinozoperekedzwa nekudzikira kweprotein yakawanda uye nekushanduka kweprotein post-translation modification.
SS-31 peptide ndeye cardiolipin peroxidase inhibitor uye mitochondrial yakananga peptide.Inogona kuvandudza basa re left ventricle uye mitochondria.SS-31 peptide inogona kuderedza kusagadzikana kwemitochondrial uye kukuvara kweoxidative mumaseru etrabecular meshwork masero.Inogona kudzivirira iHTM uye GTM (3) masero kubva kune yakagadzikana oxidative kusagadzikana inokonzerwa neH2O2.
SS-31 ndeye mitochondrial inonangisa anti-kuchembera chinhu, iyo yakaratidza kuve inoshanda mukudzoreredza basa remoyo rembeva dzakura.Iyo tetrapeptide yakagadzirwa yakasanganiswa nemitochondrial yemukati membrane, iyo inogona kuvandudza mitochondrial basa, kuderedza kugadzirwa kweiyo reactive oxygen marudzi ROS, kuderedza chiyero chezvinokonzeresa uye kunyanya kuwedzera diastolic basa remoyo.
Chekutanga, tichienzanisa mbeva diki nemakonzo ekare, masayendisiti akawana kuti kuwanda kwemapuroteni emitochondrial kunonyanya kukanganiswa nekuchembera, kusanganisira mitochondrial chiratidzo chekuchinja nzira, mapuroteni ane hukama neoxidative phosphorylation nzira inoburitsa simba, uye mapuroteni ane chekuita neSIRT chiratidzo chekufambisa nzira chine chekuita nesimba. metabolism mu mitochondria.Mukuwedzera, mapuroteni anokosha anonzi troponin uye tropomyosin, ayo anopindirana zvakananga nekuputika kwemyocardial, zviri pachena kuti anokanganisa nekukwegura.Izvi zvakanyatsoenderana nebasa remoyo.Chechipiri, kana tichifunga nezvekufuridzirwa kweSS-31 kurapwa, vatsvakurudzi vakawana kuti mapuroteni akawanda emakonzo ekare akabatwa haana kuita seanopindirana neboka rechidiki, asi vose vakaratidza kudzoreredza nzira yekusaita nekuchembera. sekuwanda kweprotein ye tricarboxylic acid cycle, nzira huru yekugadzirwa kwesimba mumuviri, iyo yakanyatsopora kusvika pamwero mukuru, zvichiita kuti mbeva dzekare dzive diki.Izvi zvinoreva kuti SS-31 inonyanya kushanda kune shanduko yesimba metabolism inokonzerwa nekukwegura kwemoyo.Ongororo yehuwandu hweprotein yakasvika kumagumo, uyezve vaongorori vakaisa pfungwa dzavo kune shanduko mukushandurwa kweprotein mushure mekushandura panguva yekuchembera, uye vakanyatsosarudza iyo inowanzoitika mushure mekushandura shanduko muprotein, inonyanyoenderana nemoyo. -acetylation kugadziriswa.Panogona kunge paine shanduko mbiri mukugadziriswa kweacetylation.Kutanga, nokuti acetylation yeprotein mitochondrial ichawedzera nezera, zvichiita kuti mitochondrial dysfunction, uye mitochondrial yemoyo yakanyanyisa, saka mwoyo wose unogona kunge uine acetylation accumulation apo basa remwoyo rinoderera;Chechipiri, pachava nekurasikirwa kwemaitiro acetylation ezvimwe zvakasara mukukwegura, izvo zvinotungamirira mukukundikana kutamba basa rayo remazuva ose.Vatsvakurudzi vakapfumisa acetylated peptides mumoyo (iyo inogona kungonzwisiswa sezvikamu zviduku zvinoshandiswa kugadzira mapuroteni).Pachine misiyano yeacetylation mamiriro emwoyo mapuroteni pakati peboka rechidiki neboka rekare, asi hazvisi pachena sekuwanda kweprotein.Ipapo ivo zvakare vakaongorora kuti ndeapi mapuroteni shanduko iyi mune acetylation chimiro inogona kuve yakananga.Pakupedzisira, vatsvakurudzi vakabatanidza zvakare simba re systolic uye diastolic yemwoyo uye vakawana 14 acetylation nzvimbo dzine chokuita nekukwanisa kwe diastolic yemoyo, uye dzose dzaive dzakashata.Panguva imwecheteyo, nzvimbo mbiri dzine chokuita nekubatana kwemwoyo dzakawanikwawo.Izvi zvinoreva kuti kuchinja kwechibvumirano panguva yekukwegura kunogona kugadziriswa neacetylation state yeprotein yemwoyo.
Isu tiri mugadziri wepolypeptide muChina, tine makore akati wandei ehunyanzvi mukugadzira polypeptide.Hangzhou Taijia Biotech Co, Ltd inyanzvi yepolypeptide mbishi kugadzira, iyo inogona kupa makumi ezviuru zvepolypeptide mbishi zvinhu uye inogona zvakare kugadzirwa zvinoenderana nezvinodiwa.Hunhu hwezvigadzirwa zvepolypeptide hwakanakisa, uye kuchena kunogona kusvika 98%, iyo yave ichizivikanwa nevashandisi pasi rese.Welcome to consult us.
