Mune gastric juice yemunhu, BPC 157 yakagadzikana kwemaawa anopfuura makumi maviri nemana, uye nokudaro ine yakanaka yemuromo bioavailability (inogara ichipiwa yoga) uye inobatsira mudumbu rose remudumbu.Uyu ndiwo musiyano unokosha kubva kune mamwe mapeptide akajairika, ayo anoshanda zvinoenderana nekuwedzera kweanotakura kana kuti anoparadzwa nekukurumidza mugastric juice. Naizvozvo, yakagadzikana BPC 157 inokurudzirwa kuva murevereri weRobert's cytoprotection, iyo inochengetedza kutendeseka ogastrointestinal mucosa.Isu tinokurudzira kuti mupiro weBPC 157 kune Robert's cytoprotection - ndiko kuti, kugona kurwisa akakosha edoro-induced gastric maronda, ayo Robert akadana cytoprotection - uye kugona kurwisa maronda anobva pakusangana kwakananga kukuvadza kweanokuvadza ane sero. inomiririra kubatana kweparipheral pakati peura uye uropi axis.
Perovic akashuma kuti BPC 157 ine chiratidzo chekurapa chine chekuita nekudzoreredzwa kwemakonzo ane musana wekukuvadzwa nemuswe muswe mitezo (1-miniti yekumanikidza kukuvadzwa kwesacrocaudal musana [S2-Co1]).Kunyanya, imwe intraperitoneal BPC 157 hutungamiri pamaminitsi e10 mushure mekukuvara kunopesana nemigumisiro yakaipa.Kusiyana neizvi, kukuvadzwa kwepelinha uye kupera kwemuswe kunopfuurira mumakonzo asina kurapwa, akaongororwa mazuva, mavhiki, mwedzi, uye gore mushure mekukuvara.Checherechedzo, BPC 157 inoderedza kukuvadzwa kunowanzokonzerwa.Nekudaro, BPC 157 kurapa inoguma mune inooneka inoshanda, microscopic, uye electrophysiologic kupora.
Zvecherechedzo, mumakonzo ane musana wekukuvadzwa, mune reperfusion zvachose.Pane imwe nguva BPC 157 inoshandiswa 10 maminetsi mushure mekukuvadzwa kwekukuvara, kune kuchengetedzwa kunoramba kuripo uye hapana kungoerekana kwaitika musana wekukuvara-kukonzeresa kukanganiswa kunowanikwazve.Kukuvadzwa kwese kwepelinha kunokurumidza kukonzeresa kubuda ropa, nekufa kunotevera kweneurons uye oligodendrocytes.
Nokudaro, zvinofungidzirwa kuti kutanga kwehemostasis kunogona kubatsira uye kugonesa kushanda kupora mushure memusana wepinal cord contusion mumakonzo.Zvisinei, mhedzisiro inoshandiswa neBPC 157 ingangove yakasiyana kubva nyore hemostatic effect iyo inogona kuderedza kukuvara kwemusana, nokuti BPC 157 inovandudza zvakanyanya kushanda kwethrombocyte mumakonzo pasina kukanganisa coagulation zvinhu.Panguva yekudzoka kubva pakukuvadzwa kwepelinha, BPC 157 inodzivirirawo zvakananga endothelium, inoderedza kuvhiringidzika kwevascular occlusion, inokurumidza kushandura dzimwe nzira dzekupfuura, uye inopesana nevenous occlusion-induced syndromes.Nokudaro, tichifunga kuti kune mupiro wakakura wevheji kumusana wemusana wekumanikidzika, zvinofungidzirwa kuti kudzoreredzwa kweropa kuyerera kunopindirana neBPC 157 pasina mubvunzo kunogona kubatsira kukurumidza kupora.Uyezve, tichifunga kuti BPC 157 inokurudzira kudzoka kwechigarire mushure mekumanikidzwa kwepelinha, zvinofanira kuonekwa kuti kana BPC 157 inopiwa panguva yekudzorerazve, inopesana nesitiroko inokonzerwa nekubatana kwepakati peiyo inowanzonzi carotid arteries.BPC 157 inogadzirisa kukuvadzwa neuronal uye inodzivirira ndangariro, locomotor, uye kushomeka kwekubatana.BPC 157 sezviri pachena inoshandisa izvi mhedzisiro nekushandura gene expression muhippocampus.
Mukupedzisa, BPC 157 ine migumisiro inobatsira pakurohwa, schizophrenia, uye kukuvara kwemusana.
Vatsvakurudzi vakaratidza nguva dzose kuti BPC 157 inoshandisa mamiriyoni emigumisiro inobatsira mumuviri wose.Hapana chikonzero chekuratidza kuti mabhenefiti eBPC 157 anoganhurirwa nekukodzera kwemamodhi akashandiswa uye / kana nzira yekugumira.Zvechokwadi, tinogona kukakavara kuti kushanda, kushandiswa nyore nyore, kuchengetedzwa kwekiriniki yehutano uye nzira yeBPC 157 inomiririra imwe nzira, inogona kubudirira, nzira yeramangwana yerapi yehutano hwehutano.Nokudaro, zvimwe zvidzidzo zvinodiwa kuti zvijekese kuti inogona sei BPC 157 therapy inogona kunyatsogadzirisa nzira yekuita iyo inosanganisira nzvimbo dzakawanda dzepasi muCNS.Kurudziro pakushanda kwevazhinji, kana zvisiri zvese, neuronal masisitimu pamamorekuru, maseru, uye systemic mazinga anofanirwa kuongororwa.Imwe visceral inodzokororwa relay yeCNS kana circumventricular nhengo, imwe yenzvimbo shoma muuropi isina ropa-brain barriers, inzira inozivikanwa iyo peptide inotungamirwa nehurongwa inogona kuita pakati.Saka, inofanirwa kuita mukati mehuku-brain axis, zvisinei nekuti chiito ichi chakananga kana kuti chisina kunanga.
